Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mitral Stenosis I: Introduction

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hemodynamic Evaluation for Mitral Valve Replacement.

Annals of biomedical engineering·2026

Same author

Reply to Comment on "Effect of Transcatheter Edge-to-Edge Repair on Left Ventricular Flow Features".

Cardiovascular engineering and technology·2025

Same author

Experimental study of the dispersion of cough-generated droplets from a person going up- or downstairs.

AIP advances·2022

Same author

Effects of space sizes on the dispersion of cough-generated droplets from a walking person.

Physics of fluids (Woodbury, N.Y. : 1994)·2020

Same author

The motion of respiratory droplets produced by coughing.

Physics of fluids (Woodbury, N.Y. : 1994)·2020

Same author

Effect of Mo on Microstructures and Wear Properties of In Situ Synthesized Ti(C,N)/Ni-Based Composite Coatings by Laser Cladding.

Materials (Basel, Switzerland)·2017

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Effect of Transcatheter Edge-to-Edge Repair on Left Ventricular Flow Features.

Xinyi He^1,2, Shuyi Feng^3,4,5,6, Fan Wu^1,2

¹The State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100190, China.

Cardiovascular Engineering and Technology

|April 3, 2025

Summary

Transcatheter edge-to-edge repair (TEER) reduces mitral regurgitation but increases harmful left ventricular (LV) shear stress and energy loss. These hemodynamic changes may negatively impact patient health and cardiac function.

Keywords:

Hemodynamics Left ventricular flow features MitraClip Mitral regurgitation TEER

More Related Videos

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

Related Experiment Videos

Last Updated: Jul 8, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

Area of Science:

Cardiovascular Research
Biomedical Engineering
Hemodynamics

Background:

Transcatheter edge-to-edge repair (TEER) is a minimally invasive procedure for mitral regurgitation (MR).
Understanding the impact of TEER on left ventricular (LV) hemodynamics is crucial for patient outcomes.

Purpose of the Study:

To investigate the effects of TEER on LV hemodynamics.
To assess potential implications for patient health and cardiac function.

Main Methods:

An in vitro experimental platform simulating LV anatomy and function was utilized.
Porcine mitral and aortic valves were integrated with a 3D-printed silicone LV model.
Echocardiography and particle image velocimetry assessed LV hemodynamics, including vorticity, Reynolds shear stress (RSS), viscous shear stress (VSS), and energy dissipation rate (ε).

Main Results:

TEER effectively reduced MR.
A significant increase in RSS, VSS, and ε was observed post-TEER.
The increase in shear stress and energy dissipation was attributed to the formation of numerous small-scale vortices within the LV.

Conclusions:

Hemodynamic alterations following TEER, including elevated shear stress and energy dissipation, may contribute to adverse LV remodeling.
Potential risks include red blood cell damage and reduced cardiac pumping efficiency.
Optimizing TEER procedures requires consideration of these hemodynamic changes to improve patient outcomes.