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Published on: August 12, 2020
Outcome reporting in neonatal septic shock studies: A systematic review
Hanmei Peng1, Jing Shi2, Jun Tang2
1Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, China; Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Neonatal septic shock research lacks standardized outcomes, hindering progress. This review identified varied reporting and calls for a core outcome set to improve consistency and clinical relevance in neonatal care.
Area of Science:
- Neonatal Medicine
- Critical Care
- Evidence Synthesis
Background:
- Neonatal septic shock is a severe condition requiring immediate, individualized treatment.
- Existing research on neonatal septic shock interventions suffers from inconsistent outcome reporting.
- This heterogeneity complicates study comparisons and limits the synthesis of evidence.
Purpose of the Study:
- To systematically review and analyze outcomes reported in studies of neonatal septic shock interventions.
- To inform the development of a core outcome set for standardized reporting.
- To improve future research and clinical practice in managing neonatal septic shock.
Main Methods:
- Systematic review conducted following the Core Outcome Measures in Effectiveness Trials (COMET) framework and PRISMA guidelines.
- Searches of PubMed, Embase, and Cochrane Library up to September 2024.
- Outcomes were extracted, standardized, and categorized using a 38-item taxonomy by four independent reviewers.
Main Results:
- 25 studies involving 4957 neonates were included, identifying 66 unique outcomes.
- Physiological/clinical outcomes were most frequent (72%), followed by death (68%), resource use (48%), and adverse events (36%).
- Outcomes related to the impact on life were notably absent in the reviewed studies.
Conclusions:
- Significant heterogeneity exists in outcome reporting for neonatal septic shock interventions.
- A critical gap in measuring life impact outcomes was identified.
- Developing a standardized core outcome set is essential for consistent and clinically relevant reporting.
