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Updated: May 15, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Iron-Cobalt Dual Catalysis for the Synthesis of Alkenyl Amino Acids and Modification of Peptides
Huan-Huan Zhao1, Xu-Gang Zhang1, Hao-Wen Jiang1
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, Gansu, China.
Abstract:
Herein, we report an Fe/Co dual-catalyzed strategy for synthesizing alkenyl unnatural amino acids and peptide modifications. This approach utilizes aspartic acid and glutamic acid derivatives as alkyl radical precursors. It avoids the use of expensive photoredox catalysts and substrate preactivation while preserving the chirality of the amino acids. Furthermore, this strategy enables both modification of peptides and the synthesis of amino-acid-based drug candidates for boron-neutron capture therapy (BNCT).
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