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Related Experiment Video

Updated: May 15, 2025

Cooling or Warming the Esophagus to Reduce Esophageal Injury During Left Atrial Ablation in the Treatment of Atrial Fibrillation
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Auxetic solution for enhanced esophageal brachytherapy applicator.

Jerome Jean-Joseph1, Nikolaus Balagiannis2, Markus W Scheppach3

  • 1Medical Physics Department, Augsburg University Hospital, Augsburg, Germany.

Journal of Contemporary Brachytherapy
|April 7, 2025
PubMed
Summary

A novel auxetic applicator for esophageal brachytherapy was developed and tested. Its unique design ensures smooth insertion and precise, reproducible dose delivery, showing promise for intra-cavitary treatments.

Keywords:
3D printingauxetic structureesophageal applicator

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Area of Science:

  • Medical Physics
  • Biomaterials Engineering
  • Radiation Oncology

Background:

  • Esophageal brachytherapy requires precise radiation delivery to target tumors while sparing healthy tissue.
  • Existing applicators may face challenges with insertion, dose conformity, and inter-fraction variations.

Purpose of the Study:

  • To present a novel auxetic applicator with four-channel catheters for esophageal brachytherapy.
  • To evaluate the feasibility and performance of this new applicator design.

Main Methods:

  • Development and construction of an auxetic applicator using a biocompatible material with a helical structure.
  • Modeling, commissioning, and insertion procedures were detailed.
  • An ex vivo trial on a porcine model was conducted, including simulations and dose calculations.

Main Results:

  • The applicator demonstrated a highly asymmetric dose distribution.
  • The auxetic helical design facilitated smooth insertion and reduced hot spot formation.
  • Simulations and dose calculations accurately predicted experimental measurements, validating the modeling approach.

Conclusions:

  • Ex vivo trials confirmed the applicator's feasibility, yielding consistent and reproducible dose distributions.
  • The novel applicator shows potential for effective and versatile use in intra-luminal and intra-cavitary brachytherapy applications.