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[Cognitive impairment in asthenic disorders].

L S Chutko1,2, S Yu Surushkina1, E A Yakovenko1

  • 1N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, St. Petersburg, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|April 8, 2025
PubMed
Summary
This summary is machine-generated.

This review examines cognitive deficits in asthenic disorders, including psychogenic asthenia and chronic fatigue syndrome. It explores neurocognitive impairments, cognitive control issues, and the efficacy of pharmacological treatments for these conditions.

Keywords:
astheniachronic fatigue syndromeciticolinecognitive fatigueneurastheniarecognan

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Asthenic disorders, including psychogenic asthenia and chronic fatigue syndrome, are characterized by significant cognitive impairments.
  • Understanding the etiology and pathogenesis of these conditions is crucial for effective management.
  • Current diagnostic criteria require clear definition and consistent application.

Purpose of the Study:

  • To review scientific literature on the cognitive aspects of asthenic disorders.
  • To explore the neurocognitive deficits associated with mental asthenia and chronic fatigue syndrome.
  • To examine the role of cognitive control impairment in adaptation disorders and asthenic conditions.

Main Methods:

  • Systematic review of scientific publications.
  • Analysis of different etiological and pathogenetic viewpoints.
  • Evaluation of diagnostic criteria.
  • Assessment of neurocognitive deficits.
  • Review of pharmacological therapy effectiveness.

Main Results:

  • Asthenic disorders exhibit notable neurocognitive deficits, particularly in cognitive control.
  • Impaired cognitive control contributes to adaptation disorders and the development of asthenic conditions.
  • Pharmacological therapies show varying degrees of effectiveness in treating asthenic disorders.

Conclusions:

  • Cognitive aspects are central to understanding and managing asthenic disorders.
  • Targeting cognitive control deficits may offer therapeutic benefits.
  • Further research is needed to optimize pharmacological interventions for asthenic conditions.