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Decellularized Extracellular Matrix-Derived Hydrogels: a Powerful Class of Biomaterials for Skeletal Muscle
Mohammed A Barajaa1, Debolina Ghosh2, Cato T Laurencin2,3,4,5,6
1Department of Biomedical Engineering, College of Engineering, Imam Abdulrahman Bin Faisal University, 34212 Dammam, Saudi Arabia.
Regenerative Engineering and Translational Medicine
|April 9, 2025
Summary
Decellularized extracellular matrix (dECM) can be processed into hydrogels to enhance skeletal muscle regeneration. These dECM-derived hydrogels show promise for muscle repair and clinical applications.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- The extracellular matrix (ECM) provides a crucial microenvironment for cell function and tissue development.
- Decellularized ECM (dECM) scaffolds have historically aided skeletal muscle regeneration.
- Recent advancements allow dECM processing into hydrogels, expanding regenerative potential.
Purpose of the Study:
- To review recent progress in dECM-derived hydrogels for skeletal muscle regenerative engineering (SMRE).
- To highlight the structure, function, and composition of skeletal muscle ECM.
- To discuss the clinical translation and considerations of dECM-derived hydrogels.
Main Methods:
- A narrative review of relevant literature.
- Screening of PubMed and bibliographic databases using specific keywords.
- Inclusion of high-cited and relevant articles.
Main Results:
- Discussion of skeletal muscle ECM's role in embryogenesis, growth, development, and repair.
- Review of various hydrogels utilized in skeletal muscle regeneration.
- Analysis of current applications and clinical translation potential of dECM-derived hydrogels in SMRE.
Conclusions:
- dECM-derived hydrogels for SMRE are an emerging field with significant potential.
- Standardizing decellularization, reducing immunogenicity, and conducting large animal studies are key for clinical advancement.
- Further research is needed to overcome current limitations and facilitate clinical translation.
