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Advantages of time-dependent diffusion MRI for quantitative microstructural mapping in breast tumors
Lei Bao1, Sijie Li2, Zhuo Wang1
1The First Hospital of Jilin University, Department of Radiology, Changchun, Jilin, China.
Frontiers in Oncology
|April 9, 2025
Summary
Time-dependent diffusion MRI (TD-MRI) effectively distinguishes malignant from benign breast tumors by analyzing tissue microstructure. This advanced imaging technique shows promise for improving breast lesion diagnostic accuracy.
Area of Science:
- Medical Imaging
- Biophysics
- Oncology
Background:
- Time-dependent diffusion MRI (TD-MRI) offers insights into tumor tissue microstructure.
- Its utility in differentiating benign from malignant breast tumors requires further investigation.
Purpose of the Study:
- To evaluate the diagnostic value of TD-MRI microstructural features for distinguishing between benign and malignant breast tumors.
- To assess the potential of TD-MRI in improving breast lesion diagnosis.
Main Methods:
- Prospective study of 72 patients (44 malignant, 28 benign breast tumors).
- Utilized the IMPULSED protocol on a 3.0-T MRI scanner.
- Analyzed data using MATLAB to derive parameters: extracellular diffusivity (Dex), intracellular volume fraction (Vin), cell diameter (Dmean), Vin/Dmean, and ADC values.
Main Results:
- Malignant tumors showed significantly lower Dmean and higher Vin and Vin/Dmean compared to benign tumors (p<0.0001).
- No significant difference in Dex between tumor types.
- Area Under the Curve (AUC) for Vin (0.92) and Vin/Dmean (0.91) exceeded that of ADC for differentiation.
Conclusions:
- TD-MRI microstructure mapping effectively differentiates benign from malignant breast tumors.
- This technique holds potential for enhancing the diagnostic accuracy of breast lesions.
