Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Connecting single-cell transcriptomes to projectomes in the mouse visual cortex.

Nature·2026

Same author

Uncovering Sex Differences in the Drosophila Ventral Nerve Cord Through Connectome Alignment.

bioRxiv : the preprint server for biology·2026

Same author

Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina.

bioRxiv : the preprint server for biology·2026

Same author

Distributed control circuits across a brain-and-cord connectome.

Nature·2026

Same author

A retinotopic wiring principle of the human brain.

bioRxiv : the preprint server for biology·2026

Same author

Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits.

Nature neuroscience·2026

Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026

Same journal

The complex truth about trust in science.

Nature·2026

Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026

Same journal

How FAIR data are helping to build trust in science.

Nature·2026

Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026

Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Primary Culture and Plasmid Electroporation of the Murine Organ of Corti.

Primary Culture and Plasmid Electroporation of the Murine Organ of Corti.

Published on: February 4, 2010

Perisomatic ultrastructure efficiently classifies cells in mouse cortex.

Leila Elabbady^1,2, Sharmishtaa Seshamani¹, Shang Mu³

¹Allen Institute for Brain Science, Seattle, WA, USA.

|April 9, 2025

Summary

This summary is machine-generated.

Researchers found that the perisomatic region of neurons is sufficient for cell-type identification. This method aids in characterizing neuronal connectivity, even for rare cell types in the mammalian neocortex.

More Related Videos

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Related Experiment Videos

Last Updated: Jun 21, 2026

Primary Culture and Plasmid Electroporation of the Murine Organ of Corti.

Primary Culture and Plasmid Electroporation of the Murine Organ of Corti.

Published on: February 4, 2010

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Area of Science:

Neuroscience
Cell Biology
Computational Biology

Background:

Mammalian neocortex exhibits remarkable cell-type diversity.
Existing mapping methods (molecular, electrophysiological, morphological) offer varied insights.
Electron microscopy provides detailed ultrastructure and connectivity data.

Purpose of the Study:

To systematically identify neuronal cell types using electron microscopy data.
To determine if the somatic region alone is sufficient for cell-type classification.
To facilitate cell-type-specific connectivity analysis.

Main Methods:

Quantitative analysis of the perisomatic region of all cells in 1 mm³ of cortex.
Utilizing features derived from electron microscopy data.
Classification of cell types based on somatic morphology and connectivity.

Main Results:

The perisomatic region is sufficient for identifying diverse neocortical cell types.
Cell types defined by connectivity patterns can be identified via somatic features.
The classification enables targeted characterization of cell-type-specific connectivity.

Conclusions:

Somatic region analysis is a powerful tool for neocortical cell-type identification.
This approach simplifies the study of neuronal connectivity, including rare cell types.
The findings advance our understanding of brain organization and function.