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Updated: Jul 30, 2026

Virtual Reality Experiments with Physiological Measures
Published on: August 29, 2018
The Physiologic Effect of Augmented Reality Simulation Versus Traditional Simulation: A Noninferiority, Randomized
Asheen Rama1, Marcos S Rojas-Pino1, Ellen Y Wang1
1The following authors are in the Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA: Asheen Rama is Clinical Assistant Professor; Ellen Y. Wang, Samuel T. Rodriguez, and Thomas J. Caruso are Clinical Professors; and Christian Jackson is a Statistician. Marcos S. Rojas-Pino and Oswaldo Rosales are Doctoral Candidates, Stanford University Graduate School of Education, Stanford, CA. The following authors are in the Stanford Chariot Program, Lucile Packard Children's Hospital Stanford, Palo Alto, CA: Man Yee Suen is a Clinical Research Coordinator, Janet Titzler and Michelle Zuniga-Hernandez are Clinical Research Assistants, and Faith Collins is a Laboratory Manager and Teacher.
Augmented reality (AR) medical simulations showed a similar impact on participants' physiological stress response compared to traditional methods. This cost-effective AR approach offers a viable alternative for healthcare training and skill development.
Area of Science:
- Medical simulation
- Physiology
- Augmented reality (AR)
Background:
- Traditional medical simulations use stress to enhance memory.
- Augmented reality (AR) simulations offer a cost-effective alternative using holograms.
- This study examined the physiological response to AR medical simulations.
Purpose of the Study:
- To investigate the physiological response to AR medical simulations.
- To compare the parasympathetic tone changes between AR and traditional simulations.
- To assess usability, ergonomics, satisfaction, and recall of AR simulations.
Main Methods:
- A noninferiority, controlled trial was conducted with healthcare workers.
- Participants were randomized to AR or traditional in situ medical simulations.
- Parasympathetic tone was measured via respiratory sinus arrhythmia (RSA); secondary outcomes included usability and recall.
Main Results:
- Both AR and traditional simulations decreased RSA during the event and increased it during recovery.
- AR simulations demonstrated a noninferior change in parasympathetic tone compared to traditional simulations.
- Usability was good (mean SUS score 70.5), with similar satisfaction and recall between groups.
Conclusions:
- AR medical simulations are noninferior to traditional simulations in altering parasympathetic tone.
- AR simulations present a cost-effective and viable option for medical training.
- Future research should explore AR for remote training and nontechnical skill development.
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