Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

5.0K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.0K
Loose Connective Tissue01:26

Loose Connective Tissue

6.8K
Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
6.8K
Hypodermis01:02

Hypodermis

3.9K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resolution of spatiotemporal building blocks in the diagnosis of cardiac sarcoidosis deconvolutes immunopathogenic mechanisms.

European heart journal·2025
Same author

Combined Adaptive Immune Mechanisms Mediate Cardiac Injury After COVID-19 Vaccination.

Circulation·2025
Same author

Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation.

Nature cardiovascular research·2024
Same author

Circulating c-Met-Expressing Memory T Cells Define Cardiac Autoimmunity.

Circulation·2022
Same author

Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in Mice.

Diabetes·2019
Same author

Adipose tissue dendritic cells in steady-state.

Immunology·2018

Related Experiment Video

Updated: May 23, 2025

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
06:56

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue

Published on: July 21, 2023

2.0K

Perivascular Adipose Tissue Niches for Modulating Immune Cell Function.

Jack Keane1, M Paula Longhi1

  • 1Biochemical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom.

Arteriosclerosis, Thrombosis, and Vascular Biology
|April 10, 2025
PubMed
Summary

Immune cells, not just fat cells, are key players in perivascular adipose tissue, regulating blood vessel health and function through complex interactions. Understanding these immune cells is crucial for vascular health.

Keywords:
adipocytesadipose tissuecell countlymphocytesmacrophages

More Related Videos

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

36.0K
Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
06:22

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Published on: October 27, 2020

3.6K

Related Experiment Videos

Last Updated: May 23, 2025

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
06:56

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue

Published on: July 21, 2023

2.0K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

36.0K
Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
06:22

Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping

Published on: October 27, 2020

3.6K

Area of Science:

  • Vascular Biology
  • Adipose Tissue Immunology
  • Cellular Interactions

Background:

  • Perivascular adipose tissue (PVAT) surrounds blood vessels and significantly impacts vascular function.
  • While adipocytes dominate PVAT by area, immune cells constitute the majority of its cell population.
  • Resident immune cells, including macrophages and lymphoid cells, play critical roles in PVAT beyond inflammation.

Purpose of the Study:

  • To review the mechanisms by which immune cells regulate PVAT function.
  • To highlight the spatial organization of immune cells within PVAT.
  • To emphasize the importance of heterotypic cellular interactions in PVAT homeostasis and disease.

Main Methods:

  • Review of existing literature on PVAT cellular composition and immune cell function.
  • Analysis of spatial organization and intercellular communication within PVAT.
  • Focus on immune cell-adipocyte and immune cell-endothelial cell interactions.

Main Results:

  • Immune cells in PVAT modulate adipogenesis, vessel integrity, and vascular contractility.
  • Complex cellular interactions, spatially coordinated, influence PVAT function.
  • Environmental factors significantly impact immune cell behavior and interactions within PVAT.

Conclusions:

  • Immune cells are critical regulators of PVAT function, impacting vascular health.
  • Spatial organization and heterotypic interactions of immune cells are central to PVAT's role in health and disease.
  • Further research into PVAT immune cell dynamics is warranted for therapeutic strategies.