DNA Hydrogels in Tissue Engineering: From Molecular Design to Next-Generation Biomedical Applications

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Nanotechnology

Background:

• DNA hydrogels are advanced materials with inherent biocompatibility, programmability, and responsiveness to stimuli.
• They are synthesized via physical and chemical crosslinking, leading to functionalized (e.g., aptamer-based) and stimuli-responsive variants (pH, temperature, light).

Purpose of the Study:

• To review the diverse applications of DNA hydrogels in tissue engineering.
• To provide a bibliometric analysis of research trends, emerging areas, and future directions in DNA hydrogel development and application.

Main Methods:

• Literature review of DNA hydrogel synthesis, functionalization, and applications.
• Bibliometric analysis to identify key research trends, influential studies, and emerging areas.
• Discussion of current challenges and future prospects, including AI integration.

Main Results:

• DNA hydrogels are utilized in drug delivery, cell culture, biosensing, and gene editing due to their ability to encapsulate therapeutics and support cell growth.
• Bibliometric analysis reveals key research trajectories and highlights the growing interest in DNA hydrogel design and biomedical applications.
• Identified challenges include mechanical strength, stability, and biosafety, with AI showing potential for future advancements.

Conclusions:

• DNA hydrogels are versatile biomaterials with significant potential in tissue engineering and regenerative medicine.
• Continued research and development, particularly in addressing limitations and leveraging AI, are crucial for realizing their full clinical potential.