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Growing choroidal osteoma: Treated by proton beam radiation
Ahad Sedaghat1, Mary E Aronow2, Arun D Singh1
1Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Taiwan Journal of Ophthalmology
|April 11, 2025
Summary
Proton beam radiation therapy effectively halted the growth of choroidal osteoma, a rare intraocular tumor, in two pediatric patients. This treatment preserved vision by stopping tumor progression toward the fovea.
Area of Science:
- Ophthalmology
- Oncology
- Medical Physics
Background:
- Choroidal osteoma is a rare, slow-growing intraocular osseous tumor.
- Management strategies for choroidal osteoma, especially when encroaching on the fovea, require further investigation.
- Intraocular tumors pose unique challenges due to their location and potential impact on vision.
Observation:
- Two cases of pediatric patients with growing choroidal osteoma were analyzed.
- One patient received proton beam radiation therapy as primary treatment for foveal-threatening growth.
- The second patient underwent proton beam radiation therapy after photodynamic therapy failed to control tumor progression.
Findings:
- Proton beam radiation therapy resulted in sustained cessation of tumor growth in both cases.
- Tumor growth was halted for 42 months in the first patient and 38 months in the second patient.
- Low-dose proton beam radiation demonstrated efficacy in managing choroidal osteoma.
Implications:
- Proton beam radiation therapy is a viable and effective treatment option for choroidal osteoma, particularly for foveal-involving lesions.
- This therapeutic approach can help preserve visual function in affected individuals.
- Long-term monitoring is crucial to assess the durability of treatment outcomes and detect any late effects.
