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Extranodal Lymphoma With Adnexal and Suspected Intracranial Involvement in a Dog
Genia R Bercovitz1, Emily A Janik1, Koichi Nagata1
1Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Veterinary Ophthalmology
|April 11, 2025
Summary
This case study details an unusual canine extranodal lymphoma presentation affecting the eyelid. Chemotherapy initially resolved the masses, but recurrence led to euthanasia, highlighting challenges in treating canine adnexal lymphoma.
Area of Science:
- Veterinary oncology
- Comparative pathology
- Ophthalmology
Background:
- An eleven-year-old dog presented with a rapidly growing eyelid mass.
- The dog had prior radiation therapy for a suspected brain glioma.
Observation:
- Biopsy revealed large B-cell lymphoma of the eyelid adnexa.
- Initial treatment with chemotherapy (modified CHOP-15) caused rapid regression.
- New masses developed, and the dog's quality of life declined.
Findings:
- Canine adnexal lymphoma can present aggressively and mimic other conditions.
- Systemic chemotherapy showed initial efficacy but not long-term control.
- Intracranial disease may be associated with extranodal lymphoma.
Implications:
- Diagnosis of adnexal lymphoma necessitates reevaluation of intracranial disease.
- This case highlights the need for effective systemic treatments for canine lymphoma.
- Further research into canine extranodal lymphoma is warranted.
