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A nomogram model based on clinical and 3D-EIT parameters for CTEPH diagnosis.

Jian Xu¹, Yuhan Wang², Ying Gong^1,3

¹Shanghai Key Laboratory of Lung Inflammation and Injury, Department of Pulmonary Medicine, Zhongshan Hospital Fudan University, Shanghai, China.

Respiratory Research

|April 12, 2025

Summary

A new nomogram model integrating clinical data and 3D electrical impedance tomography (3D-EIT) aids in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH). This tool improves diagnostic accuracy for CTEPH, a condition often misdiagnosed.

Keywords:

Chronic thromboembolic pulmonary hypertension (CTEPH)Diagnosis Electrical impedance tomography (EIT)Nomogram

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Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules

Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules

Published on: May 19, 2023

Area of Science:

Pulmonary Medicine
Medical Imaging
Diagnostic Tools

Background:

Chronic thromboembolic pulmonary hypertension (CTEPH) is frequently misdiagnosed.
Three-dimensional electrical impedance tomography (3D-EIT) offers bedside whole-lung perfusion monitoring.

Purpose of the Study:

To investigate 3D-EIT features in suspected CTEPH patients.
To construct nomogram models for identifying CTEPH using clinical and 3D-EIT data.

Main Methods:

Excluded patients with PH from left heart disease or chronic hypoxia.
Collected clinical data and performed 3D-EIT on 70 patients (50 for training).
Developed and validated a nomogram model using ROC curves, DCA, and CIC.

Main Results:

A nomogram model incorporating VTE history, D-dimer, V/Qmax, P-Range, and VQMatch was developed.
The model achieved a C-index of 0.926 in the training set.
The nomogram demonstrated superior diagnostic performance (AUC) compared to models using only clinical or EIT parameters, showing significant clinical utility.

Conclusions:

A combined nomogram model utilizing clinical and 3D-EIT parameters effectively facilitates CTEPH diagnosis.
This approach enhances diagnostic accuracy for CTEPH.