Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

2.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
2.8K
Bone Remodeling01:40

Bone Remodeling

38.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.0K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

2.9K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of fracture-related infection in low-resource settings in Africa: recommendations and guidelines from an international expert group.

Journal of bone and joint infection·2026
Same authorSame journal

Ollier's Disease Regenerate Healing Rates: Is there Cause for Concern?

Strategies in trauma and limb reconstruction·2026
Same author

Diagnosis and management of fracture-related infections in a low-income country: a prospective study comparing current practice to international consensus guidelines.

Journal of bone and joint infection·2026
Same author

Developing Up-Scale Allogeneic Chondrocyte Therapies Using Juvenile Donor Cartilage.

International journal of molecular sciences·2025
Same author

Nail plate construct in complex distal femur fractures allow safe, early unrestricted weight bearing with high rates of union and a low rate of failure: five-year experience at a UK major trauma centre.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2025
Same author

The management of idiopathic toe walking.

The bone & joint journal·2024

Related Experiment Video

Updated: May 13, 2025

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
06:41

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions

Published on: March 22, 2018

8.2K

Fitbone vs Precice: Is There a Difference in Regenerate Healing?

Peter Calder1, Alastair Robertson2, Elizabeth K Tissingh2

  • 1Department of Trauma and Orthopaedics, The Royal National Orthopaedic Hospital, Stanmore, London, England, United Kingdom.

Strategies in Trauma and Limb Reconstruction
|April 14, 2025
PubMed
Summary

This study found no significant difference in bone regenerate formation between the Fitbone and Precise intramedullary lengthening nails (ILN). Both devices successfully achieved bone consolidation and allowed for timely weight-bearing, suggesting implant choice should not solely depend on healing potential.

Keywords:
Fitbone nailIntramedullary lengthening nailPrecise nailRegenerate healing

More Related Videos

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

7.4K
Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model
09:07

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model

Published on: February 24, 2017

6.6K

Related Experiment Videos

Last Updated: May 13, 2025

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
06:41

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions

Published on: March 22, 2018

8.2K
An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

7.4K
Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model
09:07

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model

Published on: February 24, 2017

6.6K

Area of Science:

  • Orthopedic surgery
  • Biomaterials engineering
  • Regenerative medicine

Background:

  • Intramedullary lengthening nails (ILN) are established limb reconstruction tools, offering stability and precise control compared to external fixators.
  • Motorized ILNs, such as Fitbone and Precise, provide sub-millimeter accuracy and reduce complications like pin site infections.
  • The Fitbone system uses electrical current, while the Precise system employs a rotating magnet for lengthening.

Purpose of the Study:

  • To evaluate and compare bone regenerate formation after femoral lengthening using two distinct motorized ILNs: Fitbone and Precise.
  • To assess the efficacy and complication rates associated with each implant system.

Main Methods:

  • Retrospective review of 13 patients (Fitbone) and 14 patients (Precise) undergoing femoral lengthening.
  • Regenerate formation was quantified using the pixel ratio value (PVR) on serial radiographs.
  • Complications related to bone, soft tissues, and implants were meticulously recorded.

Main Results:

  • No statistical difference was observed in PVR measurements between the Fitbone and Precise groups at any time interval.
  • Full bone consolidation was achieved in all patients, with no significant difference in the time to full weight-bearing.
  • The Fitbone group experienced complications including bolt migration and premature consolidation; the Precise group reported no complications.

Conclusions:

  • Both Fitbone and Precise ILNs are effective for femoral lengthening, yielding comparable bone regenerate formation and consolidation.
  • The choice of implant should not be based on anticipated regenerate formation, as both systems perform similarly.
  • Further investigation into the Fitbone's complication rate may be warranted, potentially related to its newer technology and learning curve.