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CD121b-positive neutrophils predict immunosuppression in septic shock
Jian Chen1,2, Jinghe Zhang2,3, Siao Chen2,4
1Department of Critical Care Medicine, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.
Frontiers in Immunology
|April 15, 2025
Summary
Researchers identified CD10-CD121b+ neutrophils in septic shock patients, correlating with disease severity. Blocking CD121b increased inflammatory cytokines, suggesting CD121b as a potential immunosuppression marker in septic shock.
Area of Science:
- Immunology
- Pathophysiology
- Molecular Biology
Background:
- Septic shock presents high mortality and morbidity.
- Neutrophil involvement in septic shock requires further investigation.
Purpose of the Study:
- To investigate the role of neutrophils and CD121b in septic shock.
- To identify potential biomarkers for septic shock severity and immunosuppression.
Main Methods:
- Single-cell and batch RNA sequencing of peripheral blood immune cells from septic shock patients and healthy donors.
- Measurement of serum CD121b levels.
- In vitro analysis of immune cell responses to CD121b modulation.
- Assessment of CD121b expression in a humanized mouse sepsis model with ATRA treatment.
Main Results:
- Identification of a CD10-CD121b+ neutrophil subset in septic shock patients.
- Elevated soluble CD121b in serum and urine of patients, correlating with septic shock severity.
- CD121b+ neutrophils exhibit immunosuppressive properties; CD121b blockade enhances proinflammatory cytokine production.
- All-trans retinoic acid (ATRA) down-regulates CD121b expression.
Conclusions:
- CD121b is implicated in septic shock progression.
- CD121b may serve as a predictive biomarker for immunosuppression in septic shock.
