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Related Experiment Video

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A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
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Core-Shell Codelivery Nanocarrier Synergistically Regulates Cartilaginous Immune Microenvironment for Total Meniscus

Yajie Wang1, Bin Tang2, Menghan Zhou1

  • 1Plastic Surgery Institute, Shandong Provincial Key Laboratory for Tissue Regeneration and Repair & Reconstruction (Under Preparation), Shandong Second Medical University, Weifang, Shandong 261053, PR China.

ACS Nano
|April 16, 2025
PubMed
Summary

This study introduces a novel nanocarrier system, Em@MSN-GDF, to combat inflammation and oxidative stress in meniscus injuries. This approach successfully promotes fibrocartilage regeneration for total meniscus replacement.

Keywords:
cartilage tissue engineeringhydrogelsmeniscus repairmesoporous silicananomaterials

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Cartilage regeneration relies on a favorable microenvironment, often disrupted by inflammation and oxidative stress post-meniscus injury.
  • Total meniscus replacement faces challenges due to harsh post-injury conditions hindering tissue repair.

Purpose of the Study:

  • To develop a "core-shell" codelivery nanocarrier system for synergistic regulation of the cartilaginous immune microenvironment (CIME).
  • To enhance fibrocartilage regeneration and achieve successful total meniscus replacement.

Main Methods:

  • Mesoporous silica nanoparticles (MSNs) were engineered with Emodin (antioxidant/anti-inflammatory) in the core and growth differentiation factor (GDF) on the shell (Em@MSN-GDF).
  • Em@MSN-GDF was incorporated into hydrogels and combined with a polycaprolactone framework to create a meniscus substitute.
  • Rabbit models were used to evaluate the efficacy of the Em@MSN-GDF system in vivo.

Main Results:

  • The Em@MSN-GDF system demonstrated synergistic dual-drug release, effectively reversing the inflammatory and oxidative microenvironment.
  • Successful promotion of fibrocartilage regeneration was observed in vivo.
  • The developed meniscus substitute facilitated mechanically reinforced living tissue regeneration.

Conclusions:

  • The Em@MSN-GDF codelivery nanocarrier system offers a promising regenerative nanotreatment strategy.
  • This approach effectively reverses the harsh microenvironment associated with total meniscus replacement.
  • The study achieved successful total meniscus replacement and fibrocartilage regeneration in a rabbit model.