Inherently Chiral Seven- and Eight-Membered Rings: Enantioselective Synthesis and Applications
Yu Luo1, Shuang Luo2,3, Qiang Zhu1,2,3
1School of Pharmaceutical and Materials Engineering & Institute for Advanced Studies, Taizhou University, Taizhou, Zhejiang 318000, China.
Abstract:
Compared to smaller or larger rings, seven- and eight-membered carbo- and heterocycles are typically nonplanar and exhibit greater conformational rigidity. This property alone can impart chirality to certain 7- or 8-membered ring systems. Herein, we summarize recent achievements in the enantioselective synthesis of this class of inherently chiral medium rings, including both ring construction and ring modification, as well as the applications of chiral ligands and catalysts derived from these rigid cyclic scaffolds in asymmetric catalysis.
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