[Acute allopurinol (milurit) poisoning].

Area of Science:

• Pharmacology
• Toxicology
• Psychiatry

Background:

• Gout and schizophrenia are complex conditions requiring careful management.
• Medication adherence and overdose potential are critical considerations in psychiatric patients.

Observation:

• A patient with gout and schizophrenia experienced a severe psychotic episode.
• During this episode, the patient attempted suicide by ingesting 200 tablets (20g) of milurit.

Findings:

• The overdose resulted in acute intoxication, presenting with nausea, vomiting, diarrhea, abdominal pain, flushing, fever, and collapse.
• Laboratory findings included hepatomegaly, direct hyperbilirubinemia, elevated transaminases, leukopenia, and accelerated ESR.
• The patient recovered within 4 days following reanimation and infusion therapy.

Implications:

• This case highlights the potential for severe toxicity with milurit overdose.
• It underscores the importance of monitoring and managing patients with comorbid psychiatric and medical conditions.
• Effective reanimation and supportive care are crucial for managing milurit-induced acute intoxication.