A 0.05 mm³ diode-based single charged-particle real-time radiation detector for electron radiotherapy

Area of Science:

• Medical Physics
• Radiation Oncology
• Detector Technology

Background:

• Real-time, single-particle level radiation monitoring is crucial for advanced electron radiotherapy.
• Current methods lack the precision needed for dynamic targets and organs at risk (OARs).

Purpose of the Study:

• To develop and validate a novel CMOS-based detector for single electron sensitive real-time radiation monitoring.
• To address the unmet need for precise dosimetry in electron radiotherapy.

Main Methods:

• Development of a 0.05 mm³ CMOS chiplet integrating all necessary electronics.
• Verification of detector functionality using 6 and 9 MeV clinical electron beams.
• Measurement and Monte Carlo simulation of percentage depth vs. pulse-width curves.

Main Results:

• Demonstrated functionality of the single electron sensitive detector under clinical electron beams.
• Accurate measurement of percentage depth vs. pulse-width curves validated by simulations.
• Successful integration of electronics within a compact chiplet design.

Conclusions:

• The developed CMOS-based detector offers real-time, single-particle level radiation monitoring capabilities.
• This technology has the potential to significantly improve the quality and safety of electron radiotherapy.
• Enables simultaneous real-time dosimetry from multiple locations, enhancing treatment precision.