Related Experiment Video
Updated: May 7, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Correlation between 6PPD-Q and immune along with metabolic dysregulation induced liver lesions in outdoor workers
Zhihao Qin1, Yan Li2, Yanlan Qin2
1Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Chongqing University, 400044 Chongqing, PR China.
Abstract:
Outdoor workers who are exposed to traffic-derived pollutants often suffer from a range of diseases, with liver disease being particularly notable. Recently, a rubber stabilizing additive antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its transformed-quinone product 6PPD-quinone (6PPD-Q) attracted attention. However, their implication for human health remains inadequately elucidated. In this study, outdoor and indoor workers were recruited to analyze 6PPD and 6PPD-Q distribution in their serum and urine. Simultaneously, blood cell counts, liver function, renal function, blood glucose level, and lipid profile were evaluated by 23 physiological parameters. For the first time, we found that the concentrations of 6PPD (0.54 - 1.66 microg L-1) and 6PPD-Q (0.58 - 4.04 microg L-1) in outdoor group serum were two- and three-fold in the indoor group, respectively. Compared with indoor workers, 18 biochemical parameters, notably total bilirubin and indirect bilirubin, were elevated in outdoor workers (p < 0.05). A computed tomography scan showed liver lesions in 60% of the outdoor group, whereas only 30% of the indoor group. The statistical analysis exhibited that significant positive correlations exist between the serum 6PPD-Q and immune cell counts, total bilirubin, indirect bilirubin, and triglycerides in human beings (p < 0.05). The logistic regression implied that for each 1 microg L-1 increase of 6PPD-Q in serum, the risk of human liver lesions increased by 2.31 times. Our results suggest that outdoor exposure is associated with increased concentrations of 6PPD-Q in serum, which could potentially influence glucose and lipid metabolism, immune cell regulation, and liver health.
More Related Videos
12:15Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
Published on: May 29, 2019
11:06Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Related Concept Videos
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
Hepatitis