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Related Experiment Video

Updated: May 11, 2025

A Novel Method: Super-selective Adrenal Venous Sampling

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Primary Hypercortisolism.

Carlo Andrea Bravi¹

¹Department of Urology, Northampton General Hospital, Cliftonville, Northampton NN1 5BD, UK; Department of Urology, The Royal Marsden NHS Foundation Trust, London, UK.

The Urologic Clinics of North America

|April 18, 2025

Summary

Primary hypercortisolism, or Cushing's syndrome, involves excess cortisol production. This review details its complex diagnosis and management, covering molecular causes and clinical challenges.

Keywords:

Adrenal hyperplasia Adrenal tumor Cortisol overproduction Cushing’s syndrome Endogenous hypercortisolism Glucocorticoid excess

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Last Updated: May 11, 2025

A Novel Method: Super-selective Adrenal Venous Sampling

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Published on: September 15, 2017

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

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Cortisol Measurement in Koala Phascolarctos cinereus Fur

Cortisol Measurement in Koala Phascolarctos cinereus Fur

Published on: August 23, 2019

Area of Science:

Endocrinology
Molecular Biology
Clinical Medicine

Background:

Primary hypercortisolism (Cushing's syndrome) is an endocrine disorder caused by autonomous cortisol overproduction from the adrenal glands.
This condition leads to diverse clinical manifestations affecting metabolic, cardiovascular, and psychological health.
Management is complex due to the wide-ranging effects and diagnostic challenges.

Purpose of the Study:

To provide a comprehensive review of primary hypercortisolism.
To elucidate the pathophysiology, clinical presentation, diagnostic strategies, and treatment options.
To highlight molecular mechanisms, differential diagnosis, and clinical practice challenges.

Main Methods:

Literature review and synthesis of existing research on primary hypercortisolism.
Analysis of diagnostic criteria and therapeutic approaches.
Discussion of molecular pathways and clinical case considerations.

Main Results:

Detailed exploration of the molecular basis of cortisol overproduction.
Identification of key clinical signs and symptoms for diagnosis.
Comparison with other forms of Cushing's syndrome for accurate differential diagnosis.

Conclusions:

Primary hypercortisolism requires a multidisciplinary approach for effective management.
Understanding molecular mechanisms aids in targeted diagnostic and therapeutic strategies.
Addressing clinical challenges is crucial for improving patient outcomes in Cushing's syndrome.