The effects of selected phytochemicals on schizophrenia symptoms: A review

There are suggested treatment options for schizophrenia (SZ), including antipsychotic medications. Unfortunately, these drugs mostly ameliorate only the positive symptoms of SZ, and patients have less tendency for compliance due to the drug's side effects. Hence, there is a need for additional or adjunct therapeutic options. This review considers selected phytochemicals with anti-schizophrenic activity as an alternative therapy. We searched the scientific literature and reviewed the evidence from pre-clinical (animal) and clinical studies using some phytochemicals in SZ. The reviewed phytochemicals provided varying potential beneficial effects on SZ. Of particular interest, berberine may provide additional ameliorative advantages against the disorder. Although still nascent in scientific research, these studies suggest a potential adjunct therapeutic option against the pathophysiological pathways implicated in SZ. We recommend robust, carefully performed randomized controlled trials evaluating the role of these phytochemicals in SZ.