Linking serum leptin and TSH among metabolic syndrome patients with and without hypothyroidism

The comparison of thyroid profile and serum leptin levels among patients with metabolic syndrome who did not have hypothyroidism is of interest. Hence, we recruited 40 healthy controls and 80 patients with metabolic syndrome where 40 patients had hypothyroidism and 40 patients are without hypothyroidism. Blood sugar levels, thyroid profiles, lipid profiles and serum leptin levels were measured and compared between the metabolic syndrome and control groups. The serum leptin levels of patients with hypothyroidism were considerably higher (P=0.0001**) when compared to metabolic syndrome patients without hypothyroidism and controls. Furthermore, there was a substantial positive correlation between leptin levels and thyroid stimulating hormone (TSH). Results show that serum leptin and TSH are significantly correlated among metabolic syndrome patients with and without hypothyroidism. Thus, monitoring of leptin levels among metabolic syndrome patients with and without hypothyroidism is relevant.