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Updated: May 10, 2025
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Aging and HIV: Recent Findings in Contributing Factors
Flora Ramona Sigit Prakoeswa1,2, Faradiba Maharani3, Rochmadina Suci Bestari4
1Department of Dermatovenereology, Faculty of Medicine, Universitas Muhammadiyah Surakarta, Surakarta, Central Java, Indonesia.
AIDS Research and Treatment
|April 21, 2025
Summary
Aging with HIV presents complex health challenges. Antiretroviral therapy (ART), chronic inflammation, and lifestyle factors accelerate aging in people living with HIV (PLWH), necessitating holistic care.
Area of Science:
- Gerontology
- Infectious Diseases
- Public Health
Background:
- Aging people living with HIV (PLWH) face unique challenges.
- Factors include antiretroviral therapy (ART), chronic inflammation, coinfections, stigma, multimorbidity, and immunosuppression.
Purpose of the Study:
- To review current research on factors influencing aging with HIV.
- To identify key considerations for the health and well-being of older PLWH.
Main Methods:
- Comprehensive literature search of major electronic databases.
- Keywords included "HIV," "Aging," "Elderly," "Geriatrics," "Older Adults," "HIV Infections," and "HIV/AIDS."
Main Results:
- Older PLWH experience higher morbidity/mortality due to age-related comorbidities, cognitive impairment, and non-AIDS events.
- ART, while crucial, can accelerate aging via mitochondrial toxicity and metabolic issues.
- Lifestyle factors like smoking, substance abuse, and poor mental health worsen aging in PLWH.
Conclusions:
- Holistic approaches are essential for older PLWH, considering immunosenescence, coinfections, disease progression, ART, and lifestyle.
- Understanding these dynamics is key to improving health outcomes and quality of life for aging PLWH.
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