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Integrating Miniaturized Turbines into Microfluidic Droplet Generating Systems for Scalable Microgel Production.

Benjamin E Campbell¹, Kori Zhang², Anna Shi²

¹Department of Chemical Engineering, McGill University, Montréal, Quebec H3A 0C5, Canada.

ACS Applied Bio Materials

|April 22, 2025

Summary

The Turbinator device enhances microgel production for regenerative medicine by reducing size variation and enabling scalable manufacturing. This innovation supports industrial applications and maintains cell viability for tissue engineering.

Keywords:

droplet generator emulsification granular microdroplets microgels multiphase porous membrane soft matter

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Area of Science:

Biomaterials Science
Biotechnology
Tissue Engineering

Background:

Microgels are crucial for regenerative medicine and tissue engineering.
Current methods face challenges in producing large volumes of microgels with low polydispersity.

Purpose of the Study:

To introduce the Turbinator device for precise control of microdroplet generation.
To enable scalable and cost-effective microgel production for industrial applications.

Main Methods:

The Turbinator device was integrated with the Shirasu Porous Glass (SPG) microdroplet production system.
Finite element models were used to analyze shear stresses and droplet characteristics.
Biological assays (viability, spreading, invasion) were performed to confirm cell activity.

Main Results:

The Turbinator significantly reduced polydispersity of microdroplet sizes.
Continuous microgel production was achieved in scalable kerosene oil baths.
The method demonstrated support for fibroblast cell activity and cancer spheroid invasion.

Conclusions:

The Turbinator device offers a solution for scalable, high-quality microgel production.
This technology has significant potential for industrial manufacturing in regenerative medicine and tissue engineering.
The microgels produced maintain biological activity, crucial for therapeutic applications.