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Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

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Related Experiment Video

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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

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Primary pulmonary myxoid sarcoma: A case report.

Jong Hun Kim¹, Kyoung Min Kim²

¹Department of Thoracic and Cardiovascular Surgery, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54907, Republic of Korea.

Oncology Letters

|April 23, 2025

Summary

This summary is machine-generated.

Pulmonary myxoid sarcoma is a rare lung cancer. This case report details a diagnosis confirmed by EWSR1-CREB1 fusion, highlighting challenges in identifying this uncommon neoplasm.

Keywords:

EWSR1 EWSR1-CREB1 rearrangement primary pulmonary myxoid sarcoma

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Area of Science:

Oncology
Pulmonary Medicine
Pathology

Background:

Pulmonary myxoid sarcoma is a rare malignant neoplasm of the lung.
Its rarity and non-specific presentation pose diagnostic and therapeutic challenges.
Limited data exists on its pathogenesis, treatment, and prognosis.

Observation:

A 41-year-old male presented with a pulmonary mass.
CT revealed a ~1 cm nodule in the left lower lobe.
Initial frozen section suggested pleomorphic adenoma.

Findings:

Histology showed a myxoid matrix with spindle, stellate, and epithelioid cells.
Tumor cells had mild atypia and rare mitoses.
Immunohistochemistry was positive for vimentin, negative for myoepithelial markers.
EWSR1-CREB1 fusion confirmed the diagnosis via FISH and RT-PCR.

Implications:

This case expands the understanding of pulmonary myxoid sarcoma.
Accurate diagnosis requires integrated histological, immunohistochemical, and molecular analysis.
Further research is needed to establish optimal management strategies.