Jove
Visualize
Contact Us

Related Concept Videos

Immunological Memory01:23

Immunological Memory

412
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
412
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

65.3K
Overview
65.3K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

531
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
531
T Cell Types and Functions01:24

T Cell Types and Functions

617
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
617
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

625
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
625

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Memory regulatory T cells reprogram into protective T<sub>FH</sub> cell-like effectors in recurrent malaria.

Nature immunology·2026
Same author

A Suite of Eight <i>Toxoplasma gondii</i> Effectors Cooperates to Activate the Non-canonical NF-κB Pathway.

bioRxiv : the preprint server for biology·2026
Same author

Memory Regulatory T Cells Reprogram into Protective Tfh-like Effectors in Recurrent Malaria.

bioRxiv : the preprint server for biology·2025
Same author

Type I interferons induce guanylate-binding proteins and lysosomal defense in hepatocytes to control malaria.

Cell host & microbe·2025
Same author

Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria.

bioRxiv : the preprint server for biology·2024
Same author

Hepatocytes and the art of killing Plasmodium softly.

Trends in parasitology·2024
Same journal

Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

An MR1-specific nanobody capable of blocking MR1T cell activation.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

TGF-β controls developmental fate and functional identity of thymic γδ T cells.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same journal

Distinguishing Th17 cells as a unique subset.

Journal of immunology (Baltimore, Md. : 1950)·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 10, 2025

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

9.7K

Regulatory T cell memory: implications for malaria.

Nana Appiah Essel Charles-Chess1,2, Samarchith P Kurup1,2

  • 1Department of Cellular Biology, University of Georgia, Athens, GA, United States.

Journal of Immunology (Baltimore, Md. : 1950)
|April 23, 2025
PubMed
Summary
This summary is machine-generated.

Memory regulatory T cells (Tregs) show enhanced function upon re-exposure to antigens, particularly relevant in recurrent infections like malaria. Understanding mTreg biology is crucial for long-term immunity insights.

Keywords:
PlasmodiumT cellsTregsmalariamemory

More Related Videos

Application of Long-term cultured Interferon-&#947; Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

12.1K
New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
09:27

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

11.1K

Related Experiment Videos

Last Updated: May 10, 2025

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

9.7K
Application of Long-term cultured Interferon-&#947; Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

12.1K
New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
09:27

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

11.1K

Area of Science:

  • Immunology
  • Cellular Biology
  • Infectious Diseases

Background:

  • Regulatory T cells (Tregs) persist as memory cells (mTregs) after infections.
  • The behavior of mTregs upon antigen re-exposure is not well understood.
  • Tregs influence immune responses and disease outcomes in malaria.

Purpose of the Study:

  • To explore the biology of Treg memory.
  • To focus on the role of mTregs in malaria immunity.
  • To examine the implications of mTreg populations in long-term malaria immunity.

Main Methods:

  • Literature review of Treg memory and malaria immunology.
  • Analysis of emerging evidence on mTreg function.
  • Discussion of immunological implications.

Main Results:

  • Emerging evidence suggests mTregs have enhanced proliferation and suppressive capacity upon antigen re-encounter.
  • This enhanced function may be critical for managing recurrent infections.
  • mTreg recall is potentially significant for developing long-term immunity.

Conclusions:

  • The persistence and enhanced function of mTregs are key aspects of adaptive immunity.
  • Understanding mTreg dynamics in malaria is crucial for comprehending long-term immunity and disease control.
  • Further research into mTreg biology can inform strategies for managing infectious diseases.