Angiogenesis and targeted therapy in the tumour microenvironment: From basic to clinical practice.

Area of Science:

• Oncology
• Cell Biology
• Biomedical Engineering

Background:

• Angiogenesis is vital for tumor growth, invasion, and metastasis.
• Targeted anti-angiogenic therapies are increasingly important in cancer treatment.
• Understanding tumor endothelial cell heterogeneity is key to improving treatment efficacy.

Purpose of the Study:

• To review research on endothelial cell pathophysiology and its role in tumor angiogenesis.
• To explore endothelial cell heterogeneity using single-cell sequencing.
• To summarize current and future strategies in targeted angiogenesis therapy.

Main Methods:

• Systematic review of existing literature on angiogenesis and endothelial cells.
• Analysis of single-cell sequencing data to understand endothelial cell heterogeneity.
• Examination of tumor microenvironment interactions and their impact on angiogenesis.

Main Results:

• Angiogenesis is a critical factor in tumor progression and metastasis.
• Single-cell sequencing provides deep insights into endothelial cell diversity and function.
• Tumor microenvironment interactions significantly influence angiogenesis.

Conclusions:

• Targeted angiogenesis strategies are a major focus in cancer therapy.
• Anti-angiogenic immunotherapy and nanotechnology offer promising approaches.
• Further insights into endothelial cell biology can optimize anti-angiogenic treatments.