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Updated: Jun 12, 2025

Ex Vivo Perfusion of the Rodent Placenta
Published on: May 30, 2019
Evidence-Based Perioperative Management of Placenta Accreta Spectrum Disorder
Jennifer B Gilner1, Uma Deshmukh
1Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Duke University School of Medicine, Durham, North Carolina; and the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, BIDMC/Harvard Medical School, Boston, Massachusetts.
Placenta accreta spectrum (PAS) disorder requires specialized surgical management. Evidence-based strategies focus on preoperative anemia management, intraoperative resuscitation, and specific surgical techniques for safe delivery and reduced maternal morbidity.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Surgical Management
Background:
- Placenta accreta spectrum (PAS) is a significant cause of severe maternal morbidity, including hemorrhage and hysterectomy.
- Effective management strategies are crucial due to PAS's disproportionate contribution to obstetric complications.
Purpose of the Study:
- To outline evidence-based surgical management strategies for Placenta Accreta Spectrum (PAS) disorder.
- To highlight best practices and experimental approaches for reducing morbidity in PAS cases.
Main Methods:
- Review of established and emerging surgical management principles for PAS.
- Emphasis on preoperative optimization, intraoperative care, and specific surgical techniques.
Main Results:
- Preoperative anemia management and intraoperative resuscitation with blood products are beneficial.
- Key surgical practices include multidisciplinary team planning, careful hysterotomy site selection, and intraoperative assessment of placental adherence.
- Experimental strategies like routine cystoscopy and endovascular embolization require further research.
Conclusions:
- Standard cesarean delivery tenets should be maintained, alongside PAS-specific surgical approaches.
- Multidisciplinary planning and experienced teams are vital for managing PAS to minimize maternal morbidity.
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