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Updated: May 10, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

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Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network

Andrew B Kleist1, Martyna Szpakowska2, Lindsay J Talbot3

  • 1Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA; Medical Scientist Training Program, Medical College of Wisconsin, Milwaukee, WI, USA; MRC Laboratory of Molecular Biology, Cambridge, UK.

Cell
|April 24, 2025
PubMed

Keywords:
GPCRchemokinechemotaxisdata sciencemachine learningpolymorphismprotein-protein interactionselectivity determinantsshort linear motifunstructured protein

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