Related Experiment Video
Updated: May 10, 2025

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
Published on: November 29, 2024
Neuroprotective Role of the Novel GLP-1R Agonist Semaglutide
Akniyet Kenzheshova1, Aiman Moldasheva1, Mohamad Aljofan1,2
1Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, 010000, Kazakhstan.
Abstract:
Disturbances in insulin signaling and glucose metabolism within the brain are associated with the onset of neuronal degeneration and a reduction in synaptic activity. Research increasingly supports the therapeutic potential of GLP-1R agonists for diabetes- related neurodegenerative diseases. The incretin hormone recognized as GLP-1 is of major significance in ensuring the control of blood glucose levels and the facilitation of appropriate insulin signaling, which are also known to have neuroprotective properties against Alzheimer's disease, including the prevention of neuronal death, inhibition of Aβ accumulation, and mitigation of tau hyperphosphorylation. In contrast to other types of GLP-1R agonists, limited studies have focused on the novel GLP-1R agonist Semaglutide. The principal aim of this review is to determine the molecular mechanisms that link Alzheimer's disease and type 2 diabetes mellitus, as well as to understand the neuroprotective role of semaglutide.
More Related Videos
08:47Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
06:34New Application of an Atmospheric Pressure Plasma Jet as a Neuro-protective Agent Against Glucose Deprivation-induced Injury of SH-SY5Y Cells
Published on: October 9, 2017
Related Concept Videos
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Oral Hypoglycemic Agents: Glinides
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: Biguanides and Glitazones
Hypoglycemia and Glucagon
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...