Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects

The application background of mussel-inspired materials is based on the unique underwater adhesive ability of marine mussels, which has inspired researchers to develop bionic materials with strong adhesion, self-healing ability, biocompatibility, and environmental friendliness. Specifically, 3, 4-dihydroxyphenylalanine (DOPA) in mussel byssus is able to form non-covalent forces on a variety of surfaces, which are critical for the mussel's underwater adhesion and enable the mussel-inspired material to dissipate energy and repair itself under external forces. Mussel-inspired hydrogels are ideal medical adhesive materials due to their unique physical and chemical properties, such as excellent tissue adhesion, hemostasis and bacteriostasis, biosafety, and plasticity. This paper reviewed chitosan, cellulose, hyaluronic acid, gelatin, alginate, and other biomedical materials and discussed the advanced functions of mussel-inspired hydrogels as wound dressings, including antibacterial, anti-inflammatory, and antioxidant properties, adhesion and hemostasis, material transport, self-healing, stimulating response, and so on. At the same time, the technical challenges and limitations of the biomimetic mussel hydrogel in biomedical applications were further discussed, and its potential solutions and future research developments in the field of biomedicine were highlighted.