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Updated: May 8, 2025
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
OUTCOMES OF CRYOTHERAPY FOR THE TREATMENT OF RETINOBLASTOMA IN 92 CONSECUTIVE PATIENTS
Younghoon Kim1, Guy S Negretti2,3,4, Mark Westcott3
1Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Complications like retinal detachment and vitreous hemorrhage after cryotherapy for retinoblastoma are uncommon. While more cryotherapy sessions may raise vitreous hemorrhage risk, vision loss from this treatment is rare.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Retinal Diseases
Background:
- Cryotherapy is a treatment for retinoblastoma.
- Understanding its complications is crucial for patient management.
Purpose of the Study:
- To determine the incidence, risk factors, clinical course, and visual outcomes of rhegmatogenous retinal detachment (RRD) and vitreous hemorrhage (VH) after cryotherapy for retinoblastoma.
Main Methods:
- Retrospective review of 124 eyes in 92 patients treated with cryotherapy for retinoblastoma (January 2013 - December 2022).
Main Results:
- Rhegmatogenous retinal detachment (RRD) occurred in 6% of eyes, and vitreous hemorrhage (VH) in 7%.
- Increased cryotherapy applications and concurrent intra-arterial chemotherapy were associated with VH risk.
- Visual loss was rare, with most eyes preserving baseline vision.
Conclusions:
- Complications following cryotherapy for retinoblastoma are infrequent.
- While increased cryotherapy may elevate VH risk, cryotherapy-related visual loss is uncommon.
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