Advances in Multifunctional Nanoagents and SERS-Based Multimodal Sensing for Biotoxin in Foods

Area of Science:

• Analytical Chemistry
• Spectroscopy
• Food Science

Background:

• Biotoxins in food are a significant health concern.
• Traditional detection methods (GC-MS, ELISA) have limitations like complexity and cost.
• Surface-enhanced Raman spectroscopy (SERS) presents a sensitive and specific alternative.

Purpose of the Study:

• To review recent advancements in multimodal detection technologies based on SERS for biotoxin analysis.
• To focus on material design and classification for optimizing SERS substrates.
• To explore the integration of SERS with fluorescence, colorimetry, and electrochemistry.

Main Methods:

• Review of recent literature on SERS multimodal detection for biotoxins.
• Analysis of SERS substrate design and material classification.
• Discussion of integrated SERS systems with complementary detection techniques.

Main Results:

• SERS-based multimodal detection enhances accuracy and diversity in biotoxin identification.
• Optimized SERS substrates improve sensitivity and specificity.
• Integration with fluorescence, colorimetry, and electrochemistry broadens detection capabilities.

Conclusions:

• SERS multimodal detection shows great promise for real-time food safety monitoring.
• This technology offers potential for rapid on-site diagnostics.
• Further research is needed to address current challenges and realize future prospects.