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Interleukins in Urological Diseases
Hakan Akdere1, Burak Bilir1, Hasan Can Kuvan1
1Urology Department, Trakya University School of Medicine, 22030 Edirne, Turkey.
Discovery Medicine
|April 27, 2025
Summary
Interleukins (ILs) are key in urological diseases, impacting bladder cancer, BPH, and UTIs. Targeting IL pathways offers new diagnostic and therapeutic strategies for better patient outcomes.
Area of Science:
- Urology
- Immunology
- Oncology
Background:
- Interleukins (ILs) are critical cytokines regulating immune responses and inflammation.
- They play significant roles in the pathogenesis, diagnosis, and treatment of various urological conditions.
Purpose of the Study:
- To analyze the involvement of interleukins in specific urological diseases.
- To highlight ILs as diagnostic biomarkers and therapeutic targets.
- To emphasize IL-targeted therapies for improved outcomes.
Main Methods:
- Review of existing literature on interleukins in urological diseases.
- Analysis of ILs' roles in bladder cancer, BPH, RCC, UTIs, IC/BPS, and urolithiasis.
- Evaluation of diagnostic utility and therapeutic potential of ILs and IL-targeted therapies.
Main Results:
- Elevated IL-6, IL-8, and IL-18 correlate with disease severity in bladder cancer, RCC, and BPH.
- IL-10 shows anti-inflammatory potential for chronic conditions like BPH and IC/BPS.
- Urinary IL-6 and IL-8 demonstrate diagnostic value in UTIs and urolithiasis.
Conclusions:
- Interleukins are integral to the immunopathology of urological diseases.
- IL-targeted therapies, including IL-2 and IL-17 inhibitors, show therapeutic promise.
- Focusing on ILs enhances diagnostic and therapeutic strategies in urology.
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