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Two-Dimensional Polycyclodextrins for Strong Multivalent Host-Guest Interactions at Biointerfaces.

Zahra Goudarzi1, Zahra Mohammadi1, Reza Maleki2

  • 1Department of Chemistry, Lorestan University, Khorramabad, 6815144316, Iran.

Small (Weinheim an Der Bergstrasse, Germany)
|April 28, 2025
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Summary
This summary is machine-generated.

This study introduces novel 2D poly(β-cyclodextrin)s (2D-CDs) synthesized using graphene and boron nitride templates. These 2D-CDs exhibit multivalent interactions and show promise for inhibiting viral infections as heparin mimetics.

Keywords:
2D polymersatherosclerosismultivalent host‐guestpolycyclodextrinsvirus inhibition

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biotechnology

Background:

  • Aromatic 2D polymers are well-studied, but nonaromatic 2D polymers remain less explored.
  • Cyclodextrins (CDs) are known for host-guest interactions, but their 2D polymeric forms are novel.

Purpose of the Study:

  • To synthesize and characterize nonaromatic 2D poly(β-cyclodextrin)s (2D-CDs).
  • To investigate the influence of template materials (graphene, boron nitride) on 2D-CD size and properties.
  • To explore the potential of 2D-CDs and their sulfated derivatives (2D-CDSs) in biological applications, including antiviral activity.

Main Methods:

  • Synthesis of 2D-CDs via deposition of cyclodextrins on graphene and boron nitride templates, followed by crosslinking and template removal.
  • Characterization of 2D-CDs' lateral size and thickness (0.7 nm).
  • Modification of 2D-CDs' hydroxyl groups to sodium sulfate to create 2D-CDSs.
  • Evaluation of 2D-CDSs' virus binding ability against herpes simplex virus (HSV).

Main Results:

  • 2D-CDs with lateral sizes ranging from nanometers to millimeters were successfully synthesized.
  • Graphene templates yielded smaller 2D-CDs (hundreds of nanometers) due to stronger interactions (-224.3 kJ/mol) compared to boron nitride (millimeters, -179.4 kJ/mol).
  • Sulfated 2D-CDs (2D-CDSs) demonstrated significant virus binding capacity (IC50 = 6 µg/mL) and potential as heparin mimetics.

Conclusions:

  • 2D-CDs can be controllably synthesized with tunable sizes by selecting appropriate templates.
  • 2D-CDs and 2D-CDSs possess unique properties for multivalent host-guest and electrostatic interactions with biological systems.
  • 2D-CDSs show potential as effective antiviral agents, particularly against HSV infections, due to their heparin-mimetic properties.