Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian...

Area of Science:

• Hematology
• Immunology
• Genetics

Background:

• Marginal zone lymphoma (MZL) is a rare non-Hodgkin lymphoma.
• Diagnosis typically requires pathological biopsy.
• Novel diagnostic and therapeutic approaches are needed.

Purpose of the Study:

• Investigate causal links between 41 inflammatory cytokines and MZL.
• Utilize a two-sample bidirectional Mendelian randomization (MR) approach.
• Provide insights for rapid differential diagnosis and treatment strategies.

Main Methods:

• Employed a two-sample bidirectional Mendelian randomization (MR) analysis.
• Utilized genetic variant data from large-scale genome-wide association studies.
• Performed sensitivity analyses including MR-Egger and weighted median methods.

Main Results:

• Increased MIG and IL-10 levels associated with higher MZL risk.
• Higher B-NGF levels showed a protective effect against MZL.
• Reverse MR indicated a negative correlation between MZL and IFN-γ.

Conclusions:

• MIG, IL-10, B-NGF, and IFN-γ are potential MZL biomarkers and therapeutic targets.
• IFN-γ may play a role in MZL pathogenesis.
• Findings offer novel insights for MZL research and clinical practice.