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Variable rates of SARS-CoV-2 evolution in chronic infections

Ewan W Smith1, William L Hamilton2,3,4, Ben Warne2,3

  • 1MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom.

Plos Pathogens
|April 28, 2025
PubMed
Summary

Chronic SARS-CoV-2 infections can drive virus evolution within a host, leading to distinct viral subpopulations. A new statistical method reveals this complex within-host evolution, often underestimated by standard approaches.

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