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Yellow Jack: a modern threat to Asia-Pacific countries?
Duane J Gubler1, Kathryn A Hanley2, Thomas P Monath3
1Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. Duane.Gubler@duke-nus.edu.sg.
Npj Viruses
|April 28, 2025
Summary
Yellow fever virus could spread to the Asia Pacific, a century after a warning. Global trends may increase this risk, despite public health advances.
Area of Science:
- Epidemiology
- Virology
- Public Health
Background:
- A 1923 treatise warned of yellow fever virus (YFV) spread to the Asia Pacific.
- The region has a large susceptible population at risk of YFV infection.
Purpose of the Study:
- To commemorate the 100th anniversary of Carter's treatise.
- To assess the contemporary risk of YFV geographic spread.
- To discuss factors limiting YFV spread historically.
Main Methods:
- Review of historical data.
- Analysis of current global trends.
- Epidemiological risk assessment.
Main Results:
- Global trends suggest an increased likelihood of YFV geographic expansion.
- Despite advances, the risk of YFV reaching naive populations persists.
Conclusions:
- The threat of yellow fever virus spreading to the Asia Pacific remains relevant.
- Understanding historical limitations is crucial for future prevention strategies.
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