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Particle size effects on vapour uptake and release dynamics in metal-organic frameworks

Joshua Nicks1, Cosmin Mudure2, Jordan James1

  • 1Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK. jn694@bath.ac.uk.

Chemical Communications (Cambridge, England)
|April 29, 2025
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...