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Updated: May 9, 2025
Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
Published on: April 9, 2019
Gleason pattern 4 and active surveillance in patients with grade group 2 prostate cancer
Alessandro Uleri1, Michael Baboudjian2, Riccardo Leni3,4
1Department of Urology, North Hospital, Aix-Marseille University, APHM, Marseille, France.
Background:
To report active surveillance (AS) outcomes in patients with Grade Group (GG) 2 prostate cancer (PCa) according to the baseline amount of pattern 4 on image-guided biopsy.
Methods:
Our database includes GG2 PCa patients managed with AS in ten European centers.
Results:
In total, 104 patients were included (median pattern 4: 10%, ranges 5-40). The percentage of pattern 4 was not statistically correlated with upgrading (Spearman, r = 0.073, p = 0.5) or downgrading on confirmatory biopsy (r = -0.049, p = 0.6). The median follow-up was 33 months. In multivariable Cox regression analysis, percentage of pattern 4 was not associated with GG3 upgrading (p = 0.6) or definitive treatment (p = 0.4).
Conclusions:
Patients with GG2 PCa should not be excluded from AS solely because of grade 4 > 10% when other parameters are otherwise favorable.
