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Updated: Jun 21, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

White-Matter Connectivity and General Movements in Infants with Perinatal Brain Injury.

Ellen N Sutter^1,2,3, Jose Guerrero-Gonzalez^2,4, Cameron P Casey²

¹Department of Family Medicine and Community Health, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN 55455, USA.

|May 1, 2025

Summary

Infant brain white matter integrity, particularly connectivity, is linked to general movements, an early marker for cerebral palsy (CP). This study used MRI to explore these connections, aiding in early identification and intervention for motor disabilities.

Keywords:

cerebral palsy diffusion tensor imaging general movements assessment magnetic resonance imaging perinatal brain injury

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Last Updated: Jun 21, 2026

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Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

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Published on: August 11, 2016

Area of Science:

Neuroscience
Developmental Pediatrics
Radiology

Background:

Cerebral palsy (CP) is a common motor disability often stemming from early brain injury.
Early identification of at-risk infants is crucial for timely intervention and improved outcomes.
General Movements Assessment (GMA) predicts CP, but its neurological basis is unclear.

Purpose of the Study:

To investigate the relationship between white matter integrity and general movements in infants with perinatal brain injury.
To utilize advanced neuroimaging techniques, including diffusion-weighted MRI, tractography, and TBSS.
To compare diffusion parameters between infants with and without typical general movements.

Main Methods:

Diffusion-weighted MRI analyzed in 17 infants (12 with perinatal brain injury, 5 controls).
Tractography identified the corticospinal tract; TBSS examined broader white matter networks.
DTI and NODDI diffusion parameters compared between infants with typical and atypical general movements.

Main Results:

No overall difference in corticospinal tract integrity between groups, but asymmetries correlated with movement asymmetries.
Atypical general movements in early infancy were associated with reduced corticospinal tract integrity.
Significant white matter integrity differences found in pathways including corpus callosum and thalamic radiations.

Conclusions:

White matter integrity across multiple brain regions influences general movements.
Interhemispheric and cortical-subcortical connectivity are critical, not just corticospinal integrity.
Further research in diverse populations is needed to refine early biomarkers for neurodevelopmental impairment.