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Related Experiment Videos

Morphine-induced changes in histamine dynamics in mouse brain.

M Nishibori, R Oishi, Y Itoh

    Journal of Neurochemistry
    |September 1, 1985
    PubMed
    Summary
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    Acute morphine treatment increases histamine turnover in the brain via opioid receptors. Morphine also releases histamine from slow-turnover pools in the brain and spinal cord.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Neurochemistry

    Background:

    • Histamine (HA) plays a role in central nervous system functions.
    • Opioid receptors are involved in modulating neurotransmitter systems.
    • The interaction between morphine and histamine pathways requires further elucidation.

    Purpose of the Study:

    • To investigate the impact of acute morphine administration on histamine levels and turnover.
    • To explore the influence of morphine on different histamine pools within the brain and spinal cord.

    Main Methods:

    • Mice were treated with varying doses of morphine sulfate.
    • Levels of histamine (HA) and its metabolite tele-methylhistamine (t-MH) were measured.
    • Inhibitors of histamine synthesis (alpha-fluoromethylhistidine) and monoamine oxidase (pargyline) were used.

    Related Experiment Videos

  • Naloxone was employed to assess the role of opioid receptors.

    • Main Results:

    • Morphine alone did not alter steady-state brain histamine levels but enhanced pargyline-induced t-MH accumulation, indicating increased HA turnover.
    • This effect was reversed by naloxone, confirming involvement of opioid receptors.
    • Morphine decreased brain HA levels in mice pretreated with alpha-fluoromethylhistidine, suggesting an effect on HA synthesis or release.
    • In the spinal cord, morphine significantly reduced HA levels, where HA turnover is slow.

    Conclusions:

    • Acute morphine treatment increases the turnover of neuronal histamine in the brain through opioid receptor activation.
    • Morphine also appears to release histamine from slowly turning over pools in both the brain and spinal cord.