Endocrine Mucin Producing Sweat Gland Carcinoma Treated With Mohs Micrographic Surgery: A Systematic Review

Endocrine Mucin Producing Sweat Gland Carcinoma (EMPSGC) is a low-grade, cutaneous adnexal neoplasm. It is believed to have a potential for local recurrence as well as distant metastases in rare cases.

This study's purpose is to compare recurrence rates and outcomes between EMPSGC undergoing Mohs micrographic surgery (MMS) and traditional surgical excision.

A comprehensive review of the literature was performed using the following keywords: "Endocrine Mucin Producing Sweat Gland Carcinoma" and/or "EMPSGC" and/or "Mohs Micrographic Surgery" and/or "MMS" and/or "wide local excision" and/or "excision."

There were 17 articles and 27 patients identified between the two databases. The procedures included 17 MMS and 13 surgical excisions. Patients treated with MMS typically had a lower incidence of recurrence (11.8%). In contrast, patients treated with surgical excision had a higher recurrence rate (46.2%).

This study is limited by the small number of cases identified in our literature search and the variability in follow-up duration among the cases.

MMS demonstrated less recurrence of EMPSGC compared with surgical excision. Further research with large sample sizes would be beneficial in optimizing the surgical treatment approach for EMPSGC.

Wittmer A, Arora N, Shalabi MMK, et al. Endocrine mucin producing sweat gland carcinoma treated with Mohs micrographic surgery: a systematic review. J Drugs Dermatol. 2025;24(5):498-501. doi:10.36849/JDD.8713.