[Establishment and application progress of deaf animal models].

Area of Science:

• Oto-rhino-laryngology
• Experimental Medicine
• Public Health

Background:

• Deafness is a prevalent sensory defect impacting life quality and social development, posing a major public health challenge.
• Occupational noise-induced deafness is a growing concern, ranking as the second most common occupational disease in China.
• Animal experimental studies are vital for developing prevention and control strategies for deafness.

Purpose of the Study:

• To systematically review and present methods for establishing animal models of conductive, sensorineural, and mixed deafness.
• To provide a comprehensive reference for selecting appropriate animal strains, modeling techniques, and identification indicators.
• To highlight the application of these animal models in deafness research, including pathological mechanisms, treatment, and drug screening.

Main Methods:

• Review of literature on animal models for different types of deafness.
• Description of animal strain selection criteria.
• Explanation of modeling methods and identification indicators for conductive, sensorineural, and mixed deafness.
• Discussion of model applications in research.

Main Results:

• Established methodologies for creating and validating animal models of conductive, sensorineural, and mixed deafness.
• Identified key indicators for assessing the efficacy of these models.
• Outlined the utility of these models for studying deafness pathophysiology and evaluating interventions.

Conclusions:

• The development of standardized animal models is essential for advancing deafness research.
• These models serve as critical tools for investigating the mechanisms underlying various deafness types.
• This work provides a valuable resource for researchers aiming to develop novel therapeutic strategies and drugs for hearing loss.