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Related Experiment Video

Updated: May 12, 2025

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
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Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording.

Yan Gong1,2,3, Xiang Liu2,3,4, Zebin Jiang1,2

  • 1Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA.

Microsystems & Nanoengineering
|May 6, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a novel 3D opto-electronic array for brain research, enabling simultaneous light delivery and neural recording. Its origami-inspired design ensures mechanical stability and biocompatibility for in vivo applications.

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Area of Science:

  • Neuroscience
  • Bioengineering
  • Materials Science

Background:

  • Developing advanced tools for neuroscience research is crucial for understanding brain function.
  • Existing neural probes often face limitations in mechanical stability and biocompatibility.
  • Optogenetic and electrophysiological recording techniques require integrated devices for simultaneous stimulation and data acquisition.

Purpose of the Study:

  • To present a novel thin-film, three-dimensional (3D) opto-electronic array for simultaneous cortical illumination and neural recording.
  • To demonstrate a customizable and mechanically robust device for in vivo brain research.
  • To evaluate the biocompatibility and efficacy of the developed array.

Main Methods:

  • Fabrication of a thin-film, 3D opto-electronic array using an origami-inspired "bridge+trench" structure.
  • Integration of four addressable microscale light-emitting diodes (LEDs) and nine penetrating electrodes.
  • Customization of the 2D array's shape and dimensions prior to 3D transformation.
  • Encapsulation with polyimide and epoxy for mechanical flexibility and biocompatibility.
  • In vitro and in vivo characterization to assess device performance and efficacy.

Main Results:

  • Successful transformation of the 2D array into a 3D structure with preserved thin-film metal integrity.
  • Demonstration of addressable microscale LEDs for surface cortex illumination.
  • Simultaneous recording of light-evoked neural activities using penetrating electrodes.
  • The "bridge+trench" structure and arched base provided mechanical support for direct tissue insertion.
  • Positive results from in vitro and in vivo characterization confirming device functionality and biocompatibility.

Conclusions:

  • The developed 3D opto-electronic array offers a versatile and robust platform for advanced neuroscience research.
  • The origami-inspired design facilitates seamless 2D to 3D transformation and enhances mechanical stability.
  • The device enables simultaneous optical stimulation and electrophysiological recording with high biocompatibility, paving the way for new in vivo brain studies.