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Metal Nanocomposites as Biosensors for Biological Fluids Analysis.

Dan Chicea¹, Alexandra Nicolae-Maranciuc^1,2

¹Research Center for Complex Physical Systems, Faculty of Sciences, Lucian Blaga University of Sibiu, 550012 Sibiu, Romania.

Materials (Basel, Switzerland)

|May 7, 2025

Summary

Metal nanocomposites offer advanced biosensing for biological fluids like blood and urine. These materials enhance detection of biomarkers, toxins, and drugs, paving the way for better diagnostics.

Keywords:

biological fluids metal nanocomposite microfluidic devices sensors

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Metal nanocomposites are increasingly utilized in biosensing.
Their unique properties are ideal for analyzing complex biological fluids.
Applications span diagnostics, environmental monitoring, and drug analysis.

Purpose of the Study:

To review recent advancements in metal nanocomposite-based biosensors.
To discuss their application in detecting analytes in biological fluids.
To explore fabrication techniques, properties, and future potential.

Main Methods:

Review of literature on metal nanocomposite biosensors.
Analysis of physicochemical properties (surface area, conductivity, optical/electrochemical).
Examination of fabrication methods and their influence on performance.

Main Results:

Metal nanocomposites exhibit superior sensing capabilities due to enhanced properties.
Various fabrication techniques impact biosensor sensitivity, selectivity, and stability.
Successful detection of disease biomarkers, toxins, and drugs in biological samples.

Conclusions:

Metal nanocomposite biosensors show great promise for analyzing biological fluids.
Continued development can lead to improved diagnostic tools and personalized medicine.
Addressing current challenges is key to unlocking their full potential.