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Strontium-Doped Implant Osseointegration Under Dry Preservation Conditions: In Vitro and Rat Model-Based In Vivo
Jimin Jiang1, Yingyu Zeng1, Ibrahim El Khalil Bouhamed1
1Key Laboratory of Oral Biomedical Research of Zhejiang Province, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Cancer Center of Zhejiang University, Hangzhou, China.
A novel dry preservation technique preserves strontium-doped titanium implants, maintaining surface properties and enhancing osseointegration. This method prevents degradation and ensures long-term implant performance.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Orthopedic Research
Background:
- Titanium implants are crucial in orthopedics.
- Surface modifications enhance implant osseointegration.
- Strontium doping improves biological activity.
- Preservation methods impact implant surface integrity.
Purpose of the Study:
- To develop a dry preservation surface modification for strontium-doped pure titanium implants.
- To prevent surface degradation from environmental pollutants.
- To enhance implant osseointegration.
Main Methods:
- Developed a dry preservation method involving immersion in KCl+SrCl2 solution, air-drying, and sealed storage.
- Analyzed surface characteristics (hydrophilicity, morphology) using instrumentation.
- Assessed in vitro cell adhesion, proliferation, and osteogenic differentiation.
- Evaluated in vivo osseointegration in rat tibiae using Micro-CT, torque tests, and histology.
Main Results:
- The dry-preserved (SrP) surface maintained hydrophilicity, micro-nano morphology, and strontium ion release similar to freshly prepared (SrF) implants.
- SrP implants showed significantly better in vitro cell proliferation and osteogenic differentiation compared to non-preserved (SrN) implants.
- In vivo studies demonstrated that SrP implants achieved osseointegration comparable to SrF and significantly superior to SrN after 12 months of storage.
Conclusions:
- Dry preservation effectively maintains the nanotopography and hydrophilicity of strontium-doped titanium implants during extended storage (6-12 months).
- This method prevents premature strontium ion release, unlike wet preservation.
- The technique significantly preserves and enhances the osseointegration capabilities of strontium-doped titanium implants.
