Short and Endurance Squeeze Contractile Integral in High-Resolution Anorectal Manometry Is Correlated With Vaizey...

Area of Science:

• Gastroenterology
• Pelvic Floor Disorders
• Diagnostic Tools

Background:

• Fecal incontinence significantly impacts social function and quality of life.
• High-resolution anorectal manometry (HRAM) is a key diagnostic tool.
• Understanding manometric parameters is crucial for managing incontinence.

Purpose of the Study:

• To investigate the relationship between short squeeze contractile integral (SSCI) and endurance squeeze contractile integral (ESCI) from HRAM and fecal incontinence.
• To evaluate the diagnostic accuracy of SSCI and ESCI in predicting fecal incontinence using the Vaizey score.

Main Methods:

• HRAM was performed on 45 adult subjects (26 female, 19 male).
• Subjects completed the Vaizey incontinence score questionnaire.
• SSCI and ESCI were calculated to quantify anal sphincter contraction power.

Main Results:

• Incontinent patients (n=12) exhibited significantly lower maximum short squeeze pressure, SSCI, and ESCI compared to continent patients (n=33).
• SSCI < 65,000 mmHg·s·cm demonstrated the highest predictive accuracy (77.30%) for fecal incontinence via ROC analysis.
• Logistic regression confirmed SSCI < 65,000 mmHg·s·cm as a significant predictor (OR=7.30, p=0.009).

Conclusions:

• The novel SSCI parameter effectively assesses anal sphincter contraction power during short squeezes via HRAM.
• SSCI shows a strong correlation with fecal incontinence in adults.
• SSCI offers a more accurate correlation with the Vaizey incontinence score than traditional HRAM measurements.